In November 2023, EHESP publishes and makes available on the GitHub platform the Scannotation software developed by a team of its Department of Environmental Health Sciences (DEESSE). The aim is to improve our knowledge on human exposure to environmental chemicals (e.g., pesticides, plasticisers, personal care products). By doing an automated pre-annotation of high-resolution mass spectrometry based on a library of more than 6,000 chemical compounds, Scannotation makes it possible to best characterise the human chemical exposome*.

* all the environmental factors to which humans are exposed, from their conception to their death, as well as the interaction between the individual’s own characteristics (their genotype and phenotype) and their environment.

Read the article in Environmental Science & Technology Scientific Journal

A contribution to open access human chemical exposome research

The development of Scannotation software by the EHESP Léres team makes it possible to deploy these data analysis technology in various research projects carried out by the DEESSE department of EHESP on the characterisation of the chemical exposome, in particular for the European PARC project coordinated by ANSES which aims to improve human biomonitoring and chemical risk assessment. Scannotation is already a concrete working tool for chemical exposome research infrastructures in France and Europe such as France Exposome or EIRENE. Thanks to its open access publication, it can now be used by the entire scientific community involved in the field of biomonitoring and in environmental risk prevention policies.

A tool developed in the Laboratory for study and research in environment and health of the EHESP

Initiated in 2016 in Leres by researcher Arthur David as part of the chair of research EHESP/Sorbonne Paris-Cité, the development of this software continued from 2019 with Erwann Gilles, bio-informatician engineer and Jade Chaker, post-doctoral fellow (Léres) in collaboration with Sarah Lennon (University of Rennes) to achieve the current free access version on the GitHub platform. The development of this software is part of the “environment and health” priority area of the EHESP Strategic Plan (2019-2023) and the research axes of the Léres and team 9 of the Mixed Research Unit – UMR 1085 Irset.

Published on 30 November 2023